Depot Street Brewing Co.

Depot Street Brewing Co. is a small-batch craft brewery in Jonesborough, Tennessee, founded in 2004 and recognized as the first craft brewery in Northeast Tennessee. Its longevity makes it an early part of the Tri-Cities beer scene, with all beer brewed on site in relatively small batches. The brewery draws on a range of international beer traditions and ingredients rather than focusing on a single style, producing both ales and lagers along with nonalcoholic root beer. Depot Street operates as both a working brewery and an on-site drinking destination, giving visitors a chance to sample beer where it is produced. For travelers exploring historic Jonesborough or the broader Johnson City area, it offers a direct connection to one of Northeast Tennessee’s longest-running independent brewing operations.